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E-mail: biomed@csu.edu.cn
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Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
| Uniprot primary ID | P30551 |
| PDB ID | |
| DrugBank ID | |
| BioGrid ID | |
| GuidetoPHARMACOLOGY ID | 76 |
| PharmGKB ID | |
| KEGG ID | rno:24889 |
| DIP ID | |
| STRING ID | 10116.ENSRNOP00000063137 |
| IntAct ID | |
| DMDM | |
| BRENDA | |
| Reactome | |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 24889 |
| BindingDB | P30551 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.830 | 0.000 | 0.958 | 0.000 | 0.894 | 0.005 | 0.890 | 0.000 | 0.970 | 0.000 | 0.796 | 0.005 | Download |
| Estate fingerprints | 0.900 | 0.000 | 0.780 | 0.000 | 0.840 | 0.000 | 0.850 | 0.000 | 0.930 | 0.000 | 0.681 | 0.003 | Download |
| MACCS fingerprints | 0.886 | 0.005 | 0.854 | 0.005 | 0.870 | 0.000 | 0.872 | 0.004 | 0.950 | 0.000 | 0.742 | 0.006 | Download |
| Daylight fingerprints | 0.825 | 0.005 | 0.955 | 0.000 | 0.890 | 0.000 | 0.880 | 0.000 | 0.930 | 0.000 | 0.785 | 0.005 | Download |
| ECFP2 fingerprints | 0.968 | 0.004 | 0.938 | 0.000 | 0.953 | 0.005 | 0.955 | 0.005 | 0.990 | 0.000 | 0.911 | 0.003 | Download |
| ECFP4 fingerprints | 0.970 | 0.000 | 0.970 | 0.000 | 0.970 | 0.000 | 0.970 | 0.000 | 0.990 | 0.000 | 0.944 | 0.005 | Download |
| ECFP6 fingerprints | 0.931 | 0.003 | 0.989 | 0.000 | 0.960 | 0.000 | 0.958 | 0.004 | 0.990 | 0.000 | 0.916 | 0.005 | Download |
| Positive dataset | Negative dataset |
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E-mail: biomed@csu.edu.cn
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