Target name

P30551: Cholecystokinin receptor type A


  Protein function

Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

  Database links

Uniprot primary ID P30551
PDB ID
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID 76
PharmGKB ID
KEGG ID rno:24889
DIP ID
STRING ID 10116.ENSRNOP00000063137
IntAct ID
DMDM
BRENDA
Reactome
SignaLink
BioCyc
Entrez Gene (Gene ID) 24889
BindingDB P30551

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.830 0.000 0.958 0.000 0.894 0.005 0.890 0.000 0.970 0.000 0.796 0.005 Download
Estate fingerprints 0.900 0.000 0.780 0.000 0.840 0.000 0.850 0.000 0.930 0.000 0.681 0.003 Download
MACCS fingerprints 0.886 0.005 0.854 0.005 0.870 0.000 0.872 0.004 0.950 0.000 0.742 0.006 Download
Daylight fingerprints 0.825 0.005 0.955 0.000 0.890 0.000 0.880 0.000 0.930 0.000 0.785 0.005 Download
ECFP2 fingerprints 0.968 0.004 0.938 0.000 0.953 0.005 0.955 0.005 0.990 0.000 0.911 0.003 Download
ECFP4 fingerprints 0.970 0.000 0.970 0.000 0.970 0.000 0.970 0.000 0.990 0.000 0.944 0.005 Download
ECFP6 fingerprints 0.931 0.003 0.989 0.000 0.960 0.000 0.958 0.004 0.990 0.000 0.916 0.005 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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