Receptor for gastrin and cholecystokinin. The CKK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
| Uniprot primary ID | P30553 |
| PDB ID | |
| DrugBank ID | |
| BioGrid ID | |
| GuidetoPHARMACOLOGY ID | 77 |
| PharmGKB ID | |
| KEGG ID | rno:25706 |
| DIP ID | |
| STRING ID | 10116.ENSRNOP00000024077 |
| IntAct ID | |
| DMDM | |
| BRENDA | |
| Reactome | |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 25706 |
| BindingDB | P30553 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.922 | 0.004 | 0.938 | 0.003 | 0.930 | 0.000 | 0.930 | 0.000 | 0.960 | 0.000 | 0.859 | 0.003 | Download |
| Estate fingerprints | 0.918 | 0.004 | 0.818 | 0.005 | 0.868 | 0.004 | 0.873 | 0.005 | 0.930 | 0.000 | 0.737 | 0.009 | Download |
| MACCS fingerprints | 0.900 | 0.007 | 0.862 | 0.005 | 0.881 | 0.006 | 0.884 | 0.005 | 0.940 | 0.000 | 0.763 | 0.009 | Download |
| Daylight fingerprints | 0.834 | 0.005 | 0.868 | 0.005 | 0.851 | 0.006 | 0.849 | 0.006 | 0.901 | 0.003 | 0.704 | 0.010 | Download |
| ECFP2 fingerprints | 0.929 | 0.003 | 0.949 | 0.007 | 0.939 | 0.003 | 0.937 | 0.005 | 0.970 | 0.000 | 0.870 | 0.005 | Download |
| ECFP4 fingerprints | 0.935 | 0.005 | 0.985 | 0.003 | 0.960 | 0.000 | 0.960 | 0.000 | 0.970 | 0.000 | 0.920 | 0.000 | Download |
| ECFP6 fingerprints | 0.913 | 0.008 | 0.995 | 0.000 | 0.954 | 0.007 | 0.953 | 0.007 | 0.970 | 0.000 | 0.911 | 0.010 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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