Target name

P30553: Gastrin/cholecystokinin type B receptor


  Protein function

Receptor for gastrin and cholecystokinin. The CKK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

  Database links

Uniprot primary ID P30553
PDB ID
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID 77
PharmGKB ID
KEGG ID rno:25706
DIP ID
STRING ID 10116.ENSRNOP00000024077
IntAct ID
DMDM
BRENDA
Reactome
SignaLink
BioCyc
Entrez Gene (Gene ID) 25706
BindingDB P30553

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.922 0.004 0.938 0.003 0.930 0.000 0.930 0.000 0.960 0.000 0.859 0.003 Download
Estate fingerprints 0.918 0.004 0.818 0.005 0.868 0.004 0.873 0.005 0.930 0.000 0.737 0.009 Download
MACCS fingerprints 0.900 0.007 0.862 0.005 0.881 0.006 0.884 0.005 0.940 0.000 0.763 0.009 Download
Daylight fingerprints 0.834 0.005 0.868 0.005 0.851 0.006 0.849 0.006 0.901 0.003 0.704 0.010 Download
ECFP2 fingerprints 0.929 0.003 0.949 0.007 0.939 0.003 0.937 0.005 0.970 0.000 0.870 0.005 Download
ECFP4 fingerprints 0.935 0.005 0.985 0.003 0.960 0.000 0.960 0.000 0.970 0.000 0.920 0.000 Download
ECFP6 fingerprints 0.913 0.008 0.995 0.000 0.954 0.007 0.953 0.007 0.970 0.000 0.911 0.010 Download

  Download datasets

Positive dataset Negative dataset


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 E-mail: biomed@csu.edu.cn