Target name

P30556: Type-1 angiotensin II receptor


  Protein function

Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

  Database links

Uniprot primary ID P30556
PDB ID 1ZV0 4YAY
DrugBank ID DB01029 DB00876 DB01349 DB00678 DB08822 DB01347 DB00796
BioGrid ID 106691
GuidetoPHARMACOLOGY ID 34
PharmGKB ID PA43
KEGG ID hsa:185
DIP ID
STRING ID 9606.ENSP00000273430
IntAct ID P30556
DMDM 231519
BRENDA
Reactome R-HSA-375276 R-HSA-416476
SignaLink P30556
BioCyc
Entrez Gene (Gene ID) 185
BindingDB P30556

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.840 0.000 0.980 0.000 0.910 0.000 0.900 0.000 0.940 0.000 0.820 0.000 Download
Estate fingerprints 0.870 0.000 0.790 0.004 0.830 0.000 0.840 0.000 0.910 0.000 0.667 0.005 Download
MACCS fingerprints 0.845 0.005 0.895 0.003 0.870 0.000 0.867 0.005 0.920 0.000 0.740 0.000 Download
Daylight fingerprints 0.837 0.005 0.863 0.000 0.850 0.000 0.849 0.003 0.860 0.000 0.696 0.005 Download
ECFP2 fingerprints 0.890 0.000 0.970 0.005 0.930 0.000 0.930 0.000 0.970 0.000 0.869 0.003 Download
ECFP4 fingerprints 0.890 0.000 0.990 0.000 0.940 0.000 0.940 0.000 0.970 0.000 0.890 0.000 Download
ECFP6 fingerprints 0.880 0.000 1.000 0.000 0.940 0.000 0.930 0.000 0.970 0.000 0.880 0.000 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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