Target name

P30557: Prostaglandin E2 receptor EP3 subtype


  Protein function

Receptor for prostaglandin E2 (PGE2); the EP3 receptor may be involved in inhibition of gastric acid secretion, modulation of neurotransmitter release in central and peripheral neurons, inhibition of sodium and water reabsorption in kidney tubulus and contraction in uterine smooth muscle. The activity of this receptor can couple to both the inhibition of adenylate cyclase mediated by G(i) proteins, and to an elevation of intracellular calcium. The various forms can interact with different second messenger systems.

  Database links

Uniprot primary ID P30557
PDB ID
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID 342
PharmGKB ID
KEGG ID
DIP ID
STRING ID 10090.ENSMUSP00000043302
IntAct ID
DMDM
BRENDA
Reactome
SignaLink
BioCyc
Entrez Gene (Gene ID)
BindingDB P30557

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.905 0.007 0.941 0.005 0.923 0.005 0.923 0.005 0.980 0.000 0.851 0.007 Download
Estate fingerprints 0.852 0.004 0.840 0.009 0.846 0.005 0.848 0.004 0.935 0.005 0.693 0.008 Download
MACCS fingerprints 0.878 0.013 0.944 0.003 0.911 0.007 0.906 0.008 0.971 0.003 0.821 0.014 Download
Daylight fingerprints 0.823 0.008 0.945 0.007 0.884 0.007 0.874 0.007 0.940 0.000 0.772 0.014 Download
ECFP2 fingerprints 0.985 0.005 0.971 0.003 0.978 0.004 0.978 0.004 1.000 0.000 0.952 0.004 Download
ECFP4 fingerprints 0.990 0.000 0.986 0.005 0.988 0.004 0.988 0.004 1.000 0.000 0.972 0.006 Download
ECFP6 fingerprints 0.972 0.004 0.990 0.005 0.981 0.003 0.981 0.003 1.000 0.000 0.966 0.005 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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