Target name

P30729: D(4) dopamine receptor


  Protein function

Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Modulates the circadian rhythm of contrast sensitivity by regulating the rhythmic expression of NPAS2 in the retinal ganglion cells which in turn regulates the rhythmic expression of the ADCY1 gene in the ganglian cell layer (By similarity).

  Database links

Uniprot primary ID P30729
PDB ID
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID 217
PharmGKB ID
KEGG ID
DIP ID DIP-59866N
STRING ID 10116.ENSRNOP00000024137
IntAct ID
DMDM
BRENDA
Reactome R-RNO-418594 R-RNO-390651
SignaLink
BioCyc
Entrez Gene (Gene ID)
BindingDB P30729

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.857 0.009 0.825 0.014 0.841 0.009 0.847 0.008 0.913 0.005 0.686 0.016 Download
Estate fingerprints 0.762 0.006 0.852 0.006 0.807 0.007 0.797 0.007 0.880 0.000 0.616 0.012 Download
MACCS fingerprints 0.863 0.007 0.803 0.007 0.833 0.005 0.839 0.003 0.910 0.000 0.666 0.005 Download
Daylight fingerprints 0.780 0.008 0.814 0.008 0.797 0.007 0.794 0.007 0.851 0.003 0.592 0.013 Download
ECFP2 fingerprints 0.923 0.008 0.851 0.013 0.887 0.008 0.890 0.007 0.960 0.000 0.775 0.014 Download
ECFP4 fingerprints 0.935 0.007 0.879 0.014 0.907 0.007 0.911 0.006 0.963 0.005 0.814 0.013 Download
ECFP6 fingerprints 0.918 0.010 0.936 0.008 0.927 0.008 0.927 0.008 0.969 0.003 0.851 0.014 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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