Target name

P30872: Somatostatin receptor type 1


  Protein function

Receptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and Na(+)/H(+) exchanger via pertussis toxin insensitive G proteins.

  Database links

Uniprot primary ID P30872
PDB ID
DrugBank ID DB00104 DB06663
BioGrid ID 112629
GuidetoPHARMACOLOGY ID 355
PharmGKB ID PA36154
KEGG ID hsa:6751
DIP ID
STRING ID 9606.ENSP00000267377
IntAct ID
DMDM 401124
BRENDA
Reactome R-HSA-418594 R-HSA-375276
SignaLink
BioCyc
Entrez Gene (Gene ID) 6751
BindingDB

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.879 0.003 0.999 0.000 0.939 0.003 0.930 0.000 0.980 0.000 0.880 0.000 Download
Estate fingerprints 0.890 0.000 0.990 0.000 0.940 0.000 0.936 0.005 0.980 0.000 0.881 0.003 Download
MACCS fingerprints 0.869 0.003 0.991 0.003 0.930 0.000 0.922 0.004 0.970 0.000 0.862 0.004 Download
Daylight fingerprints 0.870 0.000 0.990 0.000 0.930 0.000 0.930 0.000 0.980 0.000 0.880 0.000 Download
ECFP2 fingerprints 0.872 0.004 1.000 0.005 0.937 0.005 0.930 0.000 0.980 0.000 0.880 0.000 Download
ECFP4 fingerprints 0.889 0.003 0.999 0.000 0.944 0.005 0.940 0.000 0.990 0.000 0.894 0.005 Download
ECFP6 fingerprints 0.850 0.000 0.996 0.000 0.923 0.005 0.920 0.000 0.990 0.000 0.860 0.000 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

The recommended browsers: Safari, Firefox, Chrome, IE(Ver.>8).
 E-mail: biomed@csu.edu.cn