Target name

P30874: Somatostatin receptor type 2


  Protein function

Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization.

  Database links

Uniprot primary ID P30874
PDB ID
DrugBank ID DB00104 DB06663 DB04894
BioGrid ID 112630
GuidetoPHARMACOLOGY ID 356
PharmGKB ID PA36155
KEGG ID hsa:6752
DIP ID
STRING ID 9606.ENSP00000350198
IntAct ID P30874
DMDM 401126
BRENDA
Reactome R-HSA-418594 R-HSA-375276
SignaLink P30874
BioCyc
Entrez Gene (Gene ID) 6752
BindingDB

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.790 0.000 0.970 0.003 0.880 0.000 0.870 0.000 0.960 0.000 0.770 0.000 Download
Estate fingerprints 0.847 0.005 0.941 0.005 0.894 0.005 0.889 0.003 0.960 0.000 0.792 0.006 Download
MACCS fingerprints 0.819 0.003 0.949 0.005 0.884 0.005 0.877 0.005 0.960 0.000 0.776 0.005 Download
Daylight fingerprints 0.800 0.000 0.960 0.000 0.880 0.000 0.870 0.000 0.931 0.003 0.779 0.003 Download
ECFP2 fingerprints 0.829 0.003 0.983 0.004 0.906 0.005 0.898 0.004 0.981 0.003 0.818 0.004 Download
ECFP4 fingerprints 0.843 0.005 0.989 0.000 0.916 0.005 0.910 0.000 0.990 0.000 0.840 0.000 Download
ECFP6 fingerprints 0.830 0.000 0.990 0.000 0.910 0.000 0.900 0.000 0.990 0.000 0.830 0.000 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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