Details-Calcnet-TargetNet

Target name

P30939: 5-hydroxytryptamine receptor 1F

Protein function

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.

Database links

Uniprot primary ID	P30939
PDB ID
DrugBank ID	DB00953 DB00952 DB06148 DB00696 DB01049 DB00669 DB00216
BioGrid ID
GuidetoPHARMACOLOGY ID	5
PharmGKB ID	PA29553
KEGG ID	hsa:3355
DIP ID
STRING ID	9606.ENSP00000322924
IntAct ID
DMDM	398967
BRENDA
Reactome	R-HSA-418594 R-HSA-390666
SignaLink
BioCyc
Entrez Gene (Gene ID)	3355
BindingDB	P30939

Model Performance Metrics

Fingerprint type	Sensitivity	SEN_std	Specificity	SPE_std	Accuracy	ACC_std	F1-score	F1-score_std	AUC	AUC_std	MCC	MCC_std	Download model
FP2 fingerprints	0.766	0.012	0.936	0.005	0.851	0.003	0.838	0.006	0.920	0.000	0.712	0.009	Download
Estate fingerprints	0.754	0.005	0.784	0.007	0.769	0.006	0.766	0.005	0.871	0.003	0.538	0.012	Download
MACCS fingerprints	0.786	0.010	0.826	0.011	0.806	0.007	0.801	0.007	0.902	0.004	0.611	0.013	Download
Daylight fingerprints	0.655	0.013	0.985	0.004	0.820	0.008	0.784	0.013	0.897	0.005	0.676	0.017	Download
ECFP2 fingerprints	0.871	0.007	0.913	0.016	0.892	0.010	0.891	0.010	0.960	0.000	0.788	0.020	Download
ECFP4 fingerprints	0.850	0.007	0.962	0.011	0.906	0.007	0.901	0.007	0.969	0.003	0.818	0.012	Download
ECFP6 fingerprints	0.780	0.012	0.976	0.004	0.878	0.006	0.865	0.010	0.969	0.003	0.774	0.013	Download

Download datasets

Positive dataset

Negative dataset