Target name

P30939: 5-hydroxytryptamine receptor 1F


  Protein function

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.

  Database links

Uniprot primary ID P30939
PDB ID
DrugBank ID DB00953 DB00952 DB06148 DB00696 DB01049 DB00669 DB00216
BioGrid ID
GuidetoPHARMACOLOGY ID 5
PharmGKB ID PA29553
KEGG ID hsa:3355
DIP ID
STRING ID 9606.ENSP00000322924
IntAct ID
DMDM 398967
BRENDA
Reactome R-HSA-418594 R-HSA-390666
SignaLink
BioCyc
Entrez Gene (Gene ID) 3355
BindingDB P30939

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.766 0.012 0.936 0.005 0.851 0.003 0.838 0.006 0.920 0.000 0.712 0.009 Download
Estate fingerprints 0.754 0.005 0.784 0.007 0.769 0.006 0.766 0.005 0.871 0.003 0.538 0.012 Download
MACCS fingerprints 0.786 0.010 0.826 0.011 0.806 0.007 0.801 0.007 0.902 0.004 0.611 0.013 Download
Daylight fingerprints 0.655 0.013 0.985 0.004 0.820 0.008 0.784 0.013 0.897 0.005 0.676 0.017 Download
ECFP2 fingerprints 0.871 0.007 0.913 0.016 0.892 0.010 0.891 0.010 0.960 0.000 0.788 0.020 Download
ECFP4 fingerprints 0.850 0.007 0.962 0.011 0.906 0.007 0.901 0.007 0.969 0.003 0.818 0.012 Download
ECFP6 fingerprints 0.780 0.012 0.976 0.004 0.878 0.006 0.865 0.010 0.969 0.003 0.774 0.013 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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