Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This receptor mediates its action by association with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Isoform 2 may act as an inhibitor of GnRH-R signaling.
| Uniprot primary ID | P30968 |
| PDB ID | |
| DrugBank ID | DB00106 DB00644 DB00666 DB01406 DB00050 DB06699 DB06719 |
| BioGrid ID | 109060 |
| GuidetoPHARMACOLOGY ID | 256 |
| PharmGKB ID | PA28800 |
| KEGG ID | hsa:2798 |
| DIP ID | |
| STRING ID | 9606.ENSP00000226413 |
| IntAct ID | |
| DMDM | 399777 |
| BRENDA | |
| Reactome | R-HSA-375281 R-HSA-416476 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 2798 |
| BindingDB | P30968 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.780 | 0.005 | 0.960 | 0.000 | 0.870 | 0.000 | 0.859 | 0.003 | 0.960 | 0.000 | 0.755 | 0.005 | Download |
| Estate fingerprints | 0.874 | 0.005 | 0.786 | 0.000 | 0.830 | 0.000 | 0.840 | 0.000 | 0.900 | 0.000 | 0.667 | 0.005 | Download |
| MACCS fingerprints | 0.880 | 0.000 | 0.858 | 0.005 | 0.869 | 0.003 | 0.870 | 0.000 | 0.950 | 0.000 | 0.734 | 0.005 | Download |
| Daylight fingerprints | 0.770 | 0.000 | 0.850 | 0.000 | 0.810 | 0.000 | 0.800 | 0.000 | 0.880 | 0.000 | 0.621 | 0.003 | Download |
| ECFP2 fingerprints | 0.910 | 0.000 | 0.970 | 0.000 | 0.940 | 0.000 | 0.940 | 0.000 | 0.989 | 0.003 | 0.882 | 0.004 | Download |
| ECFP4 fingerprints | 0.948 | 0.004 | 0.994 | 0.000 | 0.971 | 0.003 | 0.970 | 0.000 | 1.000 | 0.000 | 0.948 | 0.004 | Download |
| ECFP6 fingerprints | 0.948 | 0.004 | 0.996 | 0.000 | 0.972 | 0.004 | 0.972 | 0.004 | 1.000 | 0.000 | 0.948 | 0.004 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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