Target name

P30968: Gonadotropin-releasing hormone receptor


  Protein function

Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This receptor mediates its action by association with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Isoform 2 may act as an inhibitor of GnRH-R signaling.

  Database links

Uniprot primary ID P30968
PDB ID
DrugBank ID DB00106 DB00644 DB00666 DB01406 DB00050 DB06699 DB06719
BioGrid ID 109060
GuidetoPHARMACOLOGY ID 256
PharmGKB ID PA28800
KEGG ID hsa:2798
DIP ID
STRING ID 9606.ENSP00000226413
IntAct ID
DMDM 399777
BRENDA
Reactome R-HSA-375281 R-HSA-416476
SignaLink
BioCyc
Entrez Gene (Gene ID) 2798
BindingDB P30968

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.780 0.005 0.960 0.000 0.870 0.000 0.859 0.003 0.960 0.000 0.755 0.005 Download
Estate fingerprints 0.874 0.005 0.786 0.000 0.830 0.000 0.840 0.000 0.900 0.000 0.667 0.005 Download
MACCS fingerprints 0.880 0.000 0.858 0.005 0.869 0.003 0.870 0.000 0.950 0.000 0.734 0.005 Download
Daylight fingerprints 0.770 0.000 0.850 0.000 0.810 0.000 0.800 0.000 0.880 0.000 0.621 0.003 Download
ECFP2 fingerprints 0.910 0.000 0.970 0.000 0.940 0.000 0.940 0.000 0.989 0.003 0.882 0.004 Download
ECFP4 fingerprints 0.948 0.004 0.994 0.000 0.971 0.003 0.970 0.000 1.000 0.000 0.948 0.004 Download
ECFP6 fingerprints 0.948 0.004 0.996 0.000 0.972 0.004 0.972 0.004 1.000 0.000 0.948 0.004 Download

  Download datasets

Positive dataset Negative dataset


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 E-mail: biomed@csu.edu.cn