Target name

P30969: Gonadotropin-releasing hormone receptor


  Protein function

Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This receptor mediates its action by association with G-proteins that activate a phosphatidylinositol-calcium second messenger system.

  Database links

Uniprot primary ID P30969
PDB ID
DrugBank ID
BioGrid ID 249567
GuidetoPHARMACOLOGY ID 256
PharmGKB ID
KEGG ID rno:81668
DIP ID
STRING ID 10116.ENSRNOP00000002755
IntAct ID
DMDM
BRENDA
Reactome
SignaLink
BioCyc
Entrez Gene (Gene ID) 81668
BindingDB P30969

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.878 0.004 0.942 0.004 0.910 0.000 0.910 0.000 0.970 0.000 0.827 0.005 Download
Estate fingerprints 0.843 0.005 0.797 0.004 0.820 0.000 0.823 0.005 0.900 0.000 0.643 0.005 Download
MACCS fingerprints 0.883 0.005 0.837 0.003 0.860 0.000 0.865 0.005 0.940 0.000 0.725 0.005 Download
Daylight fingerprints 0.822 0.004 0.874 0.000 0.848 0.004 0.841 0.003 0.920 0.000 0.691 0.006 Download
ECFP2 fingerprints 0.896 0.005 0.960 0.003 0.928 0.004 0.926 0.005 0.980 0.000 0.857 0.005 Download
ECFP4 fingerprints 0.937 0.005 0.983 0.004 0.960 0.000 0.960 0.000 0.990 0.000 0.920 0.000 Download
ECFP6 fingerprints 0.931 0.003 0.989 0.000 0.960 0.000 0.960 0.000 0.990 0.000 0.921 0.003 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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