TargetNet
  Target name

P30989: Neurotensin receptor type 1

  Protein function

G-protein coupled receptor for the tridecapeptide neurotensin (NTS). Signaling is effected via G proteins that activate a phosphatidylinositol-calcium second messenger system. Signaling leads to the activation of downstream MAP kinases and protects cells against apoptosis.

  Database links
Uniprot primary ID P30989
PDB ID 2LYW
DrugBank ID
BioGrid ID 110977
GuidetoPHARMACOLOGY ID 309
PharmGKB ID PA31821
KEGG ID hsa:4923
DIP ID DIP-60977N
STRING ID 9606.ENSP00000359532
IntAct ID P30989
DMDM 62297312
BRENDA
Reactome R-HSA-375276 R-HSA-416476
SignaLink
BioCyc
Entrez Gene (Gene ID) 4923
BindingDB P30989
  Model Performance Metrics
Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.559 0.010 0.873 0.012 0.716 0.011 0.663 0.012 0.768 0.006 0.458 0.019 Download
Estate fingerprints 0.583 0.008 0.803 0.008 0.693 0.008 0.654 0.007 0.756 0.005 0.394 0.016 Download
MACCS fingerprints 0.575 0.011 0.867 0.004 0.721 0.009 0.673 0.011 0.780 0.005 0.462 0.019 Download
Daylight fingerprints 0.510 0.000 0.930 0.005 0.720 0.000 0.650 0.000 0.711 0.006 0.483 0.005 Download
ECFP2 fingerprints 0.526 0.005 0.926 0.005 0.726 0.005 0.656 0.005 0.811 0.003 0.496 0.005 Download
ECFP4 fingerprints 0.547 0.005 0.947 0.004 0.747 0.005 0.679 0.003 0.837 0.005 0.529 0.003 Download
ECFP6 fingerprints 0.535 0.005 0.971 0.003 0.753 0.005 0.682 0.006 0.821 0.006 0.560 0.008 Download
  Download datasets
Positive dataset Negative dataset

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 E-mail: biomed@csu.edu.cn