Converts testosterone (T) into 5-alpha-dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.
| Uniprot primary ID | P31213 |
| PDB ID | |
| DrugBank ID | DB01126 DB00548 DB01216 DB00421 |
| BioGrid ID | |
| GuidetoPHARMACOLOGY ID | 2633 |
| PharmGKB ID | PA36113 |
| KEGG ID | hsa:6716 |
| DIP ID | |
| STRING ID | |
| IntAct ID | |
| DMDM | 401056 |
| BRENDA | 1.3.99.5 1.3.1.22 |
| Reactome | R-HSA-193048 |
| SignaLink | |
| BioCyc | MetaCyc:HS00619-MONOMER |
| Entrez Gene (Gene ID) | 6716 |
| BindingDB | P31213 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.884 | 0.005 | 0.934 | 0.004 | 0.909 | 0.003 | 0.909 | 0.003 | 0.967 | 0.005 | 0.820 | 0.005 | Download |
| Estate fingerprints | 0.857 | 0.005 | 0.873 | 0.005 | 0.865 | 0.005 | 0.863 | 0.005 | 0.940 | 0.000 | 0.731 | 0.010 | Download |
| MACCS fingerprints | 0.910 | 0.007 | 0.950 | 0.005 | 0.930 | 0.000 | 0.928 | 0.004 | 0.980 | 0.000 | 0.859 | 0.006 | Download |
| Daylight fingerprints | 0.787 | 0.007 | 0.811 | 0.000 | 0.799 | 0.003 | 0.798 | 0.004 | 0.860 | 0.000 | 0.597 | 0.007 | Download |
| ECFP2 fingerprints | 0.871 | 0.006 | 0.977 | 0.004 | 0.924 | 0.005 | 0.920 | 0.000 | 0.980 | 0.000 | 0.854 | 0.005 | Download |
| ECFP4 fingerprints | 0.895 | 0.007 | 0.989 | 0.000 | 0.942 | 0.004 | 0.940 | 0.005 | 0.990 | 0.000 | 0.888 | 0.006 | Download |
| ECFP6 fingerprints | 0.875 | 0.007 | 0.997 | 0.000 | 0.936 | 0.005 | 0.931 | 0.006 | 0.990 | 0.000 | 0.876 | 0.007 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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