Target name

P31213: 3-oxo-5-alpha-steroid 4-dehydrogenase 2


  Protein function

Converts testosterone (T) into 5-alpha-dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.

  Database links

Uniprot primary ID P31213
PDB ID
DrugBank ID DB01126 DB00548 DB01216 DB00421
BioGrid ID
GuidetoPHARMACOLOGY ID 2633
PharmGKB ID PA36113
KEGG ID hsa:6716
DIP ID
STRING ID
IntAct ID
DMDM 401056
BRENDA 1.3.99.5 1.3.1.22
Reactome R-HSA-193048
SignaLink
BioCyc MetaCyc:HS00619-MONOMER
Entrez Gene (Gene ID) 6716
BindingDB P31213

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.884 0.005 0.934 0.004 0.909 0.003 0.909 0.003 0.967 0.005 0.820 0.005 Download
Estate fingerprints 0.857 0.005 0.873 0.005 0.865 0.005 0.863 0.005 0.940 0.000 0.731 0.010 Download
MACCS fingerprints 0.910 0.007 0.950 0.005 0.930 0.000 0.928 0.004 0.980 0.000 0.859 0.006 Download
Daylight fingerprints 0.787 0.007 0.811 0.000 0.799 0.003 0.798 0.004 0.860 0.000 0.597 0.007 Download
ECFP2 fingerprints 0.871 0.006 0.977 0.004 0.924 0.005 0.920 0.000 0.980 0.000 0.854 0.005 Download
ECFP4 fingerprints 0.895 0.007 0.989 0.000 0.942 0.004 0.940 0.005 0.990 0.000 0.888 0.006 Download
ECFP6 fingerprints 0.875 0.007 0.997 0.000 0.936 0.005 0.931 0.006 0.990 0.000 0.876 0.007 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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