Details-Calcnet-TargetNet

Target name

P31388: 5-hydroxytryptamine receptor 6

Protein function

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs (PubMed:7680751). Controls pyramidal neurons migration during corticogenesis, through the regulation of CDK5 activity (By similarity). Is an activator of TOR signaling (By similarity).

Database links

Uniprot primary ID	P31388
PDB ID
DrugBank ID
BioGrid ID	249039
GuidetoPHARMACOLOGY ID	11
PharmGKB ID
KEGG ID
DIP ID
STRING ID	10116.ENSRNOP00000064366
IntAct ID
DMDM
BRENDA
Reactome	R-RNO-390666 R-RNO-418555
SignaLink
BioCyc
Entrez Gene (Gene ID)
BindingDB	P31388

Model Performance Metrics

Fingerprint type	Sensitivity	SEN_std	Specificity	SPE_std	Accuracy	ACC_std	F1-score	F1-score_std	AUC	AUC_std	MCC	MCC_std	Download model
FP2 fingerprints	0.811	0.017	0.831	0.010	0.821	0.012	0.819	0.013	0.912	0.006	0.644	0.024	Download
Estate fingerprints	0.797	0.023	0.751	0.013	0.774	0.011	0.779	0.012	0.856	0.005	0.550	0.022	Download
MACCS fingerprints	0.809	0.006	0.859	0.010	0.834	0.007	0.832	0.006	0.905	0.005	0.668	0.010	Download
Daylight fingerprints	0.683	0.015	0.737	0.007	0.710	0.011	0.701	0.010	0.771	0.003	0.416	0.014	Download
ECFP2 fingerprints	0.910	0.012	0.806	0.017	0.858	0.015	0.865	0.012	0.940	0.005	0.721	0.026	Download
ECFP4 fingerprints	0.930	0.013	0.846	0.010	0.888	0.010	0.892	0.011	0.962	0.004	0.779	0.023	Download
ECFP6 fingerprints	0.915	0.010	0.865	0.011	0.890	0.007	0.894	0.005	0.966	0.005	0.782	0.008	Download

Download datasets

Positive dataset

Negative dataset