Target name

P31388: 5-hydroxytryptamine receptor 6


  Protein function

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs (PubMed:7680751). Controls pyramidal neurons migration during corticogenesis, through the regulation of CDK5 activity (By similarity). Is an activator of TOR signaling (By similarity).

  Database links

Uniprot primary ID P31388
PDB ID
DrugBank ID
BioGrid ID 249039
GuidetoPHARMACOLOGY ID 11
PharmGKB ID
KEGG ID
DIP ID
STRING ID 10116.ENSRNOP00000064366
IntAct ID
DMDM
BRENDA
Reactome R-RNO-390666 R-RNO-418555
SignaLink
BioCyc
Entrez Gene (Gene ID)
BindingDB P31388

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.811 0.017 0.831 0.010 0.821 0.012 0.819 0.013 0.912 0.006 0.644 0.024 Download
Estate fingerprints 0.797 0.023 0.751 0.013 0.774 0.011 0.779 0.012 0.856 0.005 0.550 0.022 Download
MACCS fingerprints 0.809 0.006 0.859 0.010 0.834 0.007 0.832 0.006 0.905 0.005 0.668 0.010 Download
Daylight fingerprints 0.683 0.015 0.737 0.007 0.710 0.011 0.701 0.010 0.771 0.003 0.416 0.014 Download
ECFP2 fingerprints 0.910 0.012 0.806 0.017 0.858 0.015 0.865 0.012 0.940 0.005 0.721 0.026 Download
ECFP4 fingerprints 0.930 0.013 0.846 0.010 0.888 0.010 0.892 0.011 0.962 0.004 0.779 0.023 Download
ECFP6 fingerprints 0.915 0.010 0.865 0.011 0.890 0.007 0.894 0.005 0.966 0.005 0.782 0.008 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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