Target name

P31421: Metabotropic glutamate receptor 2


  Protein function

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization.

  Database links

Uniprot primary ID P31421
PDB ID
DrugBank ID
BioGrid ID 246580
GuidetoPHARMACOLOGY ID 290
PharmGKB ID
KEGG ID rno:24415
DIP ID
STRING ID 10116.ENSRNOP00000017607
IntAct ID P31421
DMDM
BRENDA
Reactome R-RNO-418594 R-RNO-420499
SignaLink
BioCyc
Entrez Gene (Gene ID) 24415
BindingDB P31421

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.642 0.006 0.996 0.000 0.819 0.003 0.779 0.003 0.990 0.000 0.687 0.005 Download
Estate fingerprints 0.726 0.013 0.764 0.005 0.745 0.007 0.741 0.007 0.861 0.003 0.488 0.013 Download
MACCS fingerprints 0.785 0.005 0.831 0.007 0.808 0.004 0.802 0.004 0.918 0.004 0.619 0.006 Download
Daylight fingerprints 0.623 0.007 0.995 0.000 0.809 0.003 0.766 0.005 0.931 0.003 0.670 0.005 Download
ECFP2 fingerprints 0.952 0.004 0.964 0.005 0.958 0.004 0.958 0.004 0.990 0.000 0.910 0.005 Download
ECFP4 fingerprints 0.934 0.005 0.992 0.000 0.963 0.005 0.960 0.000 0.996 0.005 0.929 0.003 Download
ECFP6 fingerprints 0.917 0.005 0.999 0.000 0.958 0.004 0.957 0.005 0.993 0.005 0.917 0.005 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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