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E-mail: biomed@csu.edu.cn
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G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization.
| Uniprot primary ID | P31421 |
| PDB ID | |
| DrugBank ID | |
| BioGrid ID | 246580 |
| GuidetoPHARMACOLOGY ID | 290 |
| PharmGKB ID | |
| KEGG ID | rno:24415 |
| DIP ID | |
| STRING ID | 10116.ENSRNOP00000017607 |
| IntAct ID | P31421 |
| DMDM | |
| BRENDA | |
| Reactome | R-RNO-418594 R-RNO-420499 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 24415 |
| BindingDB | P31421 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.642 | 0.006 | 0.996 | 0.000 | 0.819 | 0.003 | 0.779 | 0.003 | 0.990 | 0.000 | 0.687 | 0.005 | Download |
| Estate fingerprints | 0.726 | 0.013 | 0.764 | 0.005 | 0.745 | 0.007 | 0.741 | 0.007 | 0.861 | 0.003 | 0.488 | 0.013 | Download |
| MACCS fingerprints | 0.785 | 0.005 | 0.831 | 0.007 | 0.808 | 0.004 | 0.802 | 0.004 | 0.918 | 0.004 | 0.619 | 0.006 | Download |
| Daylight fingerprints | 0.623 | 0.007 | 0.995 | 0.000 | 0.809 | 0.003 | 0.766 | 0.005 | 0.931 | 0.003 | 0.670 | 0.005 | Download |
| ECFP2 fingerprints | 0.952 | 0.004 | 0.964 | 0.005 | 0.958 | 0.004 | 0.958 | 0.004 | 0.990 | 0.000 | 0.910 | 0.005 | Download |
| ECFP4 fingerprints | 0.934 | 0.005 | 0.992 | 0.000 | 0.963 | 0.005 | 0.960 | 0.000 | 0.996 | 0.005 | 0.929 | 0.003 | Download |
| ECFP6 fingerprints | 0.917 | 0.005 | 0.999 | 0.000 | 0.958 | 0.004 | 0.957 | 0.005 | 0.993 | 0.005 | 0.917 | 0.005 | Download |
| Positive dataset | Negative dataset |
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E-mail: biomed@csu.edu.cn
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