G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. Plays an important role in the regulation of synaptic plasticity and the modulation of the neural network activity.
| Uniprot primary ID | P31424 |
| PDB ID | 1DDV |
| DrugBank ID | |
| BioGrid ID | 246583 |
| GuidetoPHARMACOLOGY ID | 293 |
| PharmGKB ID | |
| KEGG ID | rno:24418 |
| DIP ID | DIP-41263N |
| STRING ID | 10116.ENSRNOP00000022059 |
| IntAct ID | P31424 |
| DMDM | |
| BRENDA | |
| Reactome | R-RNO-420499 R-RNO-416476 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 24418 |
| BindingDB | P31424 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.842 | 0.004 | 0.958 | 0.000 | 0.900 | 0.000 | 0.890 | 0.000 | 0.960 | 0.000 | 0.800 | 0.000 | Download |
| Estate fingerprints | 0.768 | 0.004 | 0.868 | 0.005 | 0.818 | 0.004 | 0.808 | 0.004 | 0.920 | 0.000 | 0.637 | 0.005 | Download |
| MACCS fingerprints | 0.834 | 0.005 | 0.844 | 0.000 | 0.839 | 0.003 | 0.838 | 0.004 | 0.930 | 0.000 | 0.675 | 0.005 | Download |
| Daylight fingerprints | 0.681 | 0.003 | 0.819 | 0.000 | 0.750 | 0.000 | 0.730 | 0.000 | 0.830 | 0.000 | 0.501 | 0.003 | Download |
| ECFP2 fingerprints | 0.921 | 0.003 | 0.939 | 0.000 | 0.930 | 0.000 | 0.930 | 0.000 | 0.980 | 0.000 | 0.860 | 0.000 | Download |
| ECFP4 fingerprints | 0.932 | 0.004 | 0.980 | 0.000 | 0.956 | 0.005 | 0.952 | 0.004 | 0.990 | 0.000 | 0.909 | 0.006 | Download |
| ECFP6 fingerprints | 0.906 | 0.005 | 0.994 | 0.003 | 0.950 | 0.000 | 0.950 | 0.000 | 0.990 | 0.000 | 0.904 | 0.005 | Download |
| Positive dataset | Negative dataset |
The recommended browsers: Safari, Firefox, Chrome, IE(Ver.>8).
E-mail: jiedong@csu.edu.cn
 |
 |
 |
 |
 |
 |