Target name

P31424: Metabotropic glutamate receptor 5


  Protein function

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. Plays an important role in the regulation of synaptic plasticity and the modulation of the neural network activity.

  Database links

Uniprot primary ID P31424
PDB ID 1DDV
DrugBank ID
BioGrid ID 246583
GuidetoPHARMACOLOGY ID 293
PharmGKB ID
KEGG ID rno:24418
DIP ID DIP-41263N
STRING ID 10116.ENSRNOP00000022059
IntAct ID P31424
DMDM
BRENDA
Reactome R-RNO-420499 R-RNO-416476
SignaLink
BioCyc
Entrez Gene (Gene ID) 24418
BindingDB P31424

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.842 0.004 0.958 0.000 0.900 0.000 0.890 0.000 0.960 0.000 0.800 0.000 Download
Estate fingerprints 0.768 0.004 0.868 0.005 0.818 0.004 0.808 0.004 0.920 0.000 0.637 0.005 Download
MACCS fingerprints 0.834 0.005 0.844 0.000 0.839 0.003 0.838 0.004 0.930 0.000 0.675 0.005 Download
Daylight fingerprints 0.681 0.003 0.819 0.000 0.750 0.000 0.730 0.000 0.830 0.000 0.501 0.003 Download
ECFP2 fingerprints 0.921 0.003 0.939 0.000 0.930 0.000 0.930 0.000 0.980 0.000 0.860 0.000 Download
ECFP4 fingerprints 0.932 0.004 0.980 0.000 0.956 0.005 0.952 0.004 0.990 0.000 0.909 0.006 Download
ECFP6 fingerprints 0.906 0.005 0.994 0.003 0.950 0.000 0.950 0.000 0.990 0.000 0.904 0.005 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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