Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner.
| Uniprot primary ID | P31645 |
| PDB ID | |
| DrugBank ID | DB00661 DB00656 DB01142 DB06204 DB00321 DB01149 DB06148 |
| BioGrid ID | 112423 |
| GuidetoPHARMACOLOGY ID | 928 |
| PharmGKB ID | PA312 |
| KEGG ID | hsa:6532 |
| DIP ID | |
| STRING ID | 9606.ENSP00000261707 |
| IntAct ID | P31645 |
| DMDM | 400630 |
| BRENDA | |
| Reactome | |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 6532 |
| BindingDB | P31645 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.810 | 0.000 | 0.770 | 0.000 | 0.790 | 0.000 | 0.792 | 0.004 | 0.871 | 0.003 | 0.580 | 0.000 | Download |
| Estate fingerprints | 0.800 | 0.000 | 0.760 | 0.000 | 0.780 | 0.000 | 0.790 | 0.000 | 0.860 | 0.000 | 0.567 | 0.005 | Download |
| MACCS fingerprints | 0.860 | 0.000 | 0.760 | 0.000 | 0.810 | 0.000 | 0.820 | 0.000 | 0.880 | 0.000 | 0.620 | 0.000 | Download |
| Daylight fingerprints | 0.670 | 0.000 | 0.750 | 0.000 | 0.710 | 0.000 | 0.700 | 0.000 | 0.750 | 0.000 | 0.417 | 0.005 | Download |
| ECFP2 fingerprints | 0.940 | 0.000 | 0.880 | 0.005 | 0.910 | 0.000 | 0.919 | 0.003 | 0.970 | 0.000 | 0.830 | 0.000 | Download |
| ECFP4 fingerprints | 0.930 | 0.000 | 0.930 | 0.000 | 0.930 | 0.000 | 0.930 | 0.000 | 0.980 | 0.000 | 0.858 | 0.004 | Download |
| ECFP6 fingerprints | 0.911 | 0.003 | 0.929 | 0.000 | 0.920 | 0.000 | 0.920 | 0.000 | 0.970 | 0.000 | 0.844 | 0.005 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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