Target name

P31645: Sodium-dependent serotonin transporter


  Protein function

Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner.

  Database links

Uniprot primary ID P31645
PDB ID
DrugBank ID DB00661 DB00656 DB01142 DB06204 DB00321 DB01149 DB06148
BioGrid ID 112423
GuidetoPHARMACOLOGY ID 928
PharmGKB ID PA312
KEGG ID hsa:6532
DIP ID
STRING ID 9606.ENSP00000261707
IntAct ID P31645
DMDM 400630
BRENDA
Reactome
SignaLink
BioCyc
Entrez Gene (Gene ID) 6532
BindingDB P31645

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.810 0.000 0.770 0.000 0.790 0.000 0.792 0.004 0.871 0.003 0.580 0.000 Download
Estate fingerprints 0.800 0.000 0.760 0.000 0.780 0.000 0.790 0.000 0.860 0.000 0.567 0.005 Download
MACCS fingerprints 0.860 0.000 0.760 0.000 0.810 0.000 0.820 0.000 0.880 0.000 0.620 0.000 Download
Daylight fingerprints 0.670 0.000 0.750 0.000 0.710 0.000 0.700 0.000 0.750 0.000 0.417 0.005 Download
ECFP2 fingerprints 0.940 0.000 0.880 0.005 0.910 0.000 0.919 0.003 0.970 0.000 0.830 0.000 Download
ECFP4 fingerprints 0.930 0.000 0.930 0.000 0.930 0.000 0.930 0.000 0.980 0.000 0.858 0.004 Download
ECFP6 fingerprints 0.911 0.003 0.929 0.000 0.920 0.000 0.920 0.000 0.970 0.000 0.844 0.005 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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