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E-mail: biomed@csu.edu.cn
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Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner (By similarity).
| Uniprot primary ID | P31652 |
| PDB ID | |
| DrugBank ID | |
| BioGrid ID | |
| GuidetoPHARMACOLOGY ID | 928 |
| PharmGKB ID | |
| KEGG ID | rno:25553 |
| DIP ID | |
| STRING ID | 10116.ENSRNOP00000004717 |
| IntAct ID | P31652 |
| DMDM | |
| BRENDA | |
| Reactome | |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 25553 |
| BindingDB | P31652 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.870 | 0.000 | 0.846 | 0.000 | 0.858 | 0.004 | 0.860 | 0.000 | 0.930 | 0.000 | 0.710 | 0.000 | Download |
| Estate fingerprints | 0.865 | 0.005 | 0.835 | 0.000 | 0.850 | 0.000 | 0.850 | 0.000 | 0.920 | 0.000 | 0.694 | 0.005 | Download |
| MACCS fingerprints | 0.872 | 0.004 | 0.828 | 0.003 | 0.850 | 0.000 | 0.850 | 0.000 | 0.920 | 0.000 | 0.691 | 0.003 | Download |
| Daylight fingerprints | 0.761 | 0.003 | 0.779 | 0.000 | 0.770 | 0.000 | 0.770 | 0.000 | 0.820 | 0.000 | 0.539 | 0.003 | Download |
| ECFP2 fingerprints | 0.946 | 0.005 | 0.894 | 0.003 | 0.920 | 0.000 | 0.921 | 0.003 | 0.970 | 0.000 | 0.843 | 0.005 | Download |
| ECFP4 fingerprints | 0.933 | 0.005 | 0.931 | 0.000 | 0.932 | 0.004 | 0.932 | 0.004 | 0.980 | 0.000 | 0.867 | 0.005 | Download |
| ECFP6 fingerprints | 0.910 | 0.000 | 0.940 | 0.000 | 0.925 | 0.005 | 0.922 | 0.004 | 0.980 | 0.000 | 0.850 | 0.000 | Download |
| Positive dataset | Negative dataset |
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E-mail: biomed@csu.edu.cn
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