DNA deaminase (cytidine deaminase) with restriction activity against viruses, foreign DNA and mobility of retrotransposons. Exhibits antiviral activity against adeno-associated virus (AAV) and human T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons. Selectively targets single-stranded DNA and can deaminate both methylcytosine and cytosine in foreign DNA. Can induce somatic hypermutation in the nuclear and mitochondrial DNA. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.
| Uniprot primary ID | P31941 |
| PDB ID | 2M65 4XXO |
| DrugBank ID | |
| BioGrid ID | 128318 |
| GuidetoPHARMACOLOGY ID | |
| PharmGKB ID | PA24891 |
| KEGG ID | hsa:100913187 |
| DIP ID | DIP-61365N |
| STRING ID | 9606.ENSP00000249116 |
| IntAct ID | |
| DMDM | 12644206 |
| BRENDA | |
| Reactome | |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 200315;100913187 |
| BindingDB | P31941 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.787 | 0.005 | 0.799 | 0.007 | 0.793 | 0.007 | 0.791 | 0.006 | 0.870 | 0.000 | 0.584 | 0.010 | Download |
| Estate fingerprints | 0.773 | 0.011 | 0.797 | 0.005 | 0.785 | 0.005 | 0.784 | 0.005 | 0.858 | 0.004 | 0.573 | 0.009 | Download |
| MACCS fingerprints | 0.730 | 0.008 | 0.806 | 0.007 | 0.768 | 0.008 | 0.758 | 0.008 | 0.850 | 0.000 | 0.537 | 0.014 | Download |
| Daylight fingerprints | 0.585 | 0.005 | 0.753 | 0.004 | 0.669 | 0.003 | 0.639 | 0.003 | 0.750 | 0.000 | 0.337 | 0.005 | Download |
| ECFP2 fingerprints | 0.869 | 0.006 | 0.885 | 0.007 | 0.877 | 0.005 | 0.876 | 0.005 | 0.960 | 0.000 | 0.752 | 0.008 | Download |
| ECFP4 fingerprints | 0.888 | 0.009 | 0.876 | 0.008 | 0.882 | 0.006 | 0.882 | 0.006 | 0.958 | 0.004 | 0.762 | 0.006 | Download |
| ECFP6 fingerprints | 0.864 | 0.005 | 0.866 | 0.010 | 0.865 | 0.005 | 0.865 | 0.005 | 0.950 | 0.000 | 0.732 | 0.008 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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