Target name

P31941: DNA dC->dU-editing enzyme APOBEC-3A


  Protein function

DNA deaminase (cytidine deaminase) with restriction activity against viruses, foreign DNA and mobility of retrotransposons. Exhibits antiviral activity against adeno-associated virus (AAV) and human T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons. Selectively targets single-stranded DNA and can deaminate both methylcytosine and cytosine in foreign DNA. Can induce somatic hypermutation in the nuclear and mitochondrial DNA. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.

  Database links

Uniprot primary ID P31941
PDB ID 2M65 4XXO
DrugBank ID
BioGrid ID 128318
GuidetoPHARMACOLOGY ID
PharmGKB ID PA24891
KEGG ID hsa:100913187
DIP ID DIP-61365N
STRING ID 9606.ENSP00000249116
IntAct ID
DMDM 12644206
BRENDA
Reactome
SignaLink
BioCyc
Entrez Gene (Gene ID) 200315;100913187
BindingDB P31941

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.787 0.005 0.799 0.007 0.793 0.007 0.791 0.006 0.870 0.000 0.584 0.010 Download
Estate fingerprints 0.773 0.011 0.797 0.005 0.785 0.005 0.784 0.005 0.858 0.004 0.573 0.009 Download
MACCS fingerprints 0.730 0.008 0.806 0.007 0.768 0.008 0.758 0.008 0.850 0.000 0.537 0.014 Download
Daylight fingerprints 0.585 0.005 0.753 0.004 0.669 0.003 0.639 0.003 0.750 0.000 0.337 0.005 Download
ECFP2 fingerprints 0.869 0.006 0.885 0.007 0.877 0.005 0.876 0.005 0.960 0.000 0.752 0.008 Download
ECFP4 fingerprints 0.888 0.009 0.876 0.008 0.882 0.006 0.882 0.006 0.958 0.004 0.762 0.006 Download
ECFP6 fingerprints 0.864 0.005 0.866 0.010 0.865 0.005 0.865 0.005 0.950 0.000 0.732 0.008 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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