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E-mail: biomed@csu.edu.cn
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Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
| Uniprot primary ID | P32238 |
| PDB ID | 1D6G 1HZN 1PB2 |
| DrugBank ID | DB00403 |
| BioGrid ID | 107328 |
| GuidetoPHARMACOLOGY ID | 76 |
| PharmGKB ID | PA26142 |
| KEGG ID | hsa:886 |
| DIP ID | |
| STRING ID | 9606.ENSP00000295589 |
| IntAct ID | P32238 |
| DMDM | 416772 |
| BRENDA | |
| Reactome | R-HSA-375276 R-HSA-416476 |
| SignaLink | P32238 |
| BioCyc | |
| Entrez Gene (Gene ID) | 886 |
| BindingDB | P32238 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.914 | 0.005 | 0.946 | 0.005 | 0.930 | 0.000 | 0.930 | 0.000 | 0.972 | 0.004 | 0.860 | 0.000 | Download |
| Estate fingerprints | 0.780 | 0.000 | 0.780 | 0.000 | 0.780 | 0.000 | 0.780 | 0.000 | 0.890 | 0.000 | 0.566 | 0.005 | Download |
| MACCS fingerprints | 0.791 | 0.003 | 0.877 | 0.004 | 0.834 | 0.005 | 0.830 | 0.000 | 0.930 | 0.000 | 0.671 | 0.003 | Download |
| Daylight fingerprints | 0.780 | 0.005 | 0.938 | 0.000 | 0.859 | 0.003 | 0.846 | 0.005 | 0.940 | 0.000 | 0.725 | 0.005 | Download |
| ECFP2 fingerprints | 0.899 | 0.006 | 0.941 | 0.004 | 0.920 | 0.005 | 0.920 | 0.005 | 0.980 | 0.000 | 0.844 | 0.007 | Download |
| ECFP4 fingerprints | 0.972 | 0.004 | 0.976 | 0.005 | 0.974 | 0.005 | 0.974 | 0.005 | 0.990 | 0.000 | 0.948 | 0.004 | Download |
| ECFP6 fingerprints | 0.919 | 0.003 | 0.981 | 0.000 | 0.950 | 0.000 | 0.950 | 0.000 | 0.990 | 0.000 | 0.906 | 0.005 | Download |
| Positive dataset | Negative dataset |
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E-mail: biomed@csu.edu.cn
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