Target name

P32238: Cholecystokinin receptor type A


  Protein function

Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

  Database links

Uniprot primary ID P32238
PDB ID 1D6G 1HZN 1PB2
DrugBank ID DB00403
BioGrid ID 107328
GuidetoPHARMACOLOGY ID 76
PharmGKB ID PA26142
KEGG ID hsa:886
DIP ID
STRING ID 9606.ENSP00000295589
IntAct ID P32238
DMDM 416772
BRENDA
Reactome R-HSA-375276 R-HSA-416476
SignaLink P32238
BioCyc
Entrez Gene (Gene ID) 886
BindingDB P32238

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.914 0.005 0.946 0.005 0.930 0.000 0.930 0.000 0.972 0.004 0.860 0.000 Download
Estate fingerprints 0.780 0.000 0.780 0.000 0.780 0.000 0.780 0.000 0.890 0.000 0.566 0.005 Download
MACCS fingerprints 0.791 0.003 0.877 0.004 0.834 0.005 0.830 0.000 0.930 0.000 0.671 0.003 Download
Daylight fingerprints 0.780 0.005 0.938 0.000 0.859 0.003 0.846 0.005 0.940 0.000 0.725 0.005 Download
ECFP2 fingerprints 0.899 0.006 0.941 0.004 0.920 0.005 0.920 0.005 0.980 0.000 0.844 0.007 Download
ECFP4 fingerprints 0.972 0.004 0.976 0.005 0.974 0.005 0.974 0.005 0.990 0.000 0.948 0.004 Download
ECFP6 fingerprints 0.919 0.003 0.981 0.000 0.950 0.000 0.950 0.000 0.990 0.000 0.906 0.005 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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