Receptor for gastrin and cholecystokinin. The CKK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
| Uniprot primary ID | P32239 |
| PDB ID | 1L4T |
| DrugBank ID | DB00183 |
| BioGrid ID | 107329 |
| GuidetoPHARMACOLOGY ID | 77 |
| PharmGKB ID | PA26143 |
| KEGG ID | hsa:887 |
| DIP ID | DIP-229N |
| STRING ID | 9606.ENSP00000335544 |
| IntAct ID | P32239 |
| DMDM | 417029 |
| BRENDA | |
| Reactome | R-HSA-881907 R-HSA-375276 R-HSA-416476 |
| SignaLink | P32239 |
| BioCyc | |
| Entrez Gene (Gene ID) | 887 |
| BindingDB | P32239 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.939 | 0.003 | 0.959 | 0.000 | 0.949 | 0.003 | 0.948 | 0.004 | 0.980 | 0.000 | 0.895 | 0.005 | Download |
| Estate fingerprints | 0.943 | 0.005 | 0.817 | 0.000 | 0.880 | 0.000 | 0.890 | 0.000 | 0.950 | 0.000 | 0.770 | 0.000 | Download |
| MACCS fingerprints | 0.953 | 0.005 | 0.903 | 0.005 | 0.928 | 0.004 | 0.930 | 0.000 | 0.970 | 0.000 | 0.852 | 0.004 | Download |
| Daylight fingerprints | 0.893 | 0.005 | 0.967 | 0.000 | 0.930 | 0.000 | 0.925 | 0.005 | 0.968 | 0.004 | 0.858 | 0.004 | Download |
| ECFP2 fingerprints | 0.980 | 0.000 | 0.956 | 0.000 | 0.968 | 0.004 | 0.970 | 0.000 | 0.990 | 0.000 | 0.931 | 0.003 | Download |
| ECFP4 fingerprints | 0.980 | 0.000 | 0.980 | 0.004 | 0.980 | 0.000 | 0.980 | 0.000 | 0.999 | 0.003 | 0.960 | 0.000 | Download |
| ECFP6 fingerprints | 0.947 | 0.005 | 0.983 | 0.000 | 0.965 | 0.005 | 0.965 | 0.005 | 0.990 | 0.000 | 0.930 | 0.000 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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