Target name

P32239: Gastrin/cholecystokinin type B receptor


  Protein function

Receptor for gastrin and cholecystokinin. The CKK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

  Database links

Uniprot primary ID P32239
PDB ID 1L4T
DrugBank ID DB00183
BioGrid ID 107329
GuidetoPHARMACOLOGY ID 77
PharmGKB ID PA26143
KEGG ID hsa:887
DIP ID DIP-229N
STRING ID 9606.ENSP00000335544
IntAct ID P32239
DMDM 417029
BRENDA
Reactome R-HSA-881907 R-HSA-375276 R-HSA-416476
SignaLink P32239
BioCyc
Entrez Gene (Gene ID) 887
BindingDB P32239

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.939 0.003 0.959 0.000 0.949 0.003 0.948 0.004 0.980 0.000 0.895 0.005 Download
Estate fingerprints 0.943 0.005 0.817 0.000 0.880 0.000 0.890 0.000 0.950 0.000 0.770 0.000 Download
MACCS fingerprints 0.953 0.005 0.903 0.005 0.928 0.004 0.930 0.000 0.970 0.000 0.852 0.004 Download
Daylight fingerprints 0.893 0.005 0.967 0.000 0.930 0.000 0.925 0.005 0.968 0.004 0.858 0.004 Download
ECFP2 fingerprints 0.980 0.000 0.956 0.000 0.968 0.004 0.970 0.000 0.990 0.000 0.931 0.003 Download
ECFP4 fingerprints 0.980 0.000 0.980 0.004 0.980 0.000 0.980 0.000 0.999 0.003 0.960 0.000 Download
ECFP6 fingerprints 0.947 0.005 0.983 0.000 0.965 0.005 0.965 0.005 0.990 0.000 0.930 0.000 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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