TargetNet
  Target name

P32240: Prostaglandin E2 receptor EP4 subtype

  Protein function

Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function.

  Database links
Uniprot primary ID P32240
PDB ID
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID 343
PharmGKB ID
KEGG ID
DIP ID
STRING ID 10090.ENSMUSP00000048736
IntAct ID
DMDM
BRENDA
Reactome R-MMU-418555 R-MMU-391908
SignaLink
BioCyc
Entrez Gene (Gene ID) 19219
BindingDB P32240
  Model Performance Metrics
Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.842 0.004 0.982 0.000 0.912 0.004 0.910 0.000 0.978 0.004 0.832 0.004 Download
Estate fingerprints 0.932 0.009 0.900 0.009 0.916 0.007 0.916 0.007 0.957 0.005 0.830 0.012 Download
MACCS fingerprints 0.920 0.005 0.918 0.004 0.919 0.003 0.919 0.003 0.975 0.005 0.837 0.005 Download
Daylight fingerprints 0.852 0.004 0.848 0.005 0.850 0.000 0.851 0.003 0.898 0.004 0.699 0.006 Download
ECFP2 fingerprints 0.950 0.000 0.996 0.000 0.973 0.005 0.973 0.005 0.998 0.004 0.950 0.000 Download
ECFP4 fingerprints 0.993 0.007 0.999 0.000 0.996 0.005 0.996 0.005 1.000 0.000 0.993 0.007 Download
ECFP6 fingerprints 0.975 0.007 0.999 0.000 0.987 0.005 0.987 0.005 1.000 0.000 0.975 0.007 Download
  Download datasets
Positive dataset Negative dataset

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 E-mail: biomed@csu.edu.cn