TargetNet
  Target name

P32245: Melanocortin receptor 4

  Protein function

Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP).

  Database links
Uniprot primary ID P32245
PDB ID 2IQP 2IQR 2IQS 2IQU 2IQV 2IQW
DrugBank ID
BioGrid ID 110330
GuidetoPHARMACOLOGY ID 285
PharmGKB ID PA30676
KEGG ID hsa:4160
DIP ID DIP-48791N
STRING ID 9606.ENSP00000299766
IntAct ID P32245
DMDM 60392672
BRENDA
Reactome R-HSA-418555 R-HSA-375276
SignaLink
BioCyc
Entrez Gene (Gene ID) 4160
BindingDB P32245
  Model Performance Metrics
Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.910 0.000 0.890 0.000 0.900 0.000 0.900 0.000 0.950 0.000 0.800 0.000 Download
Estate fingerprints 0.868 0.004 0.796 0.000 0.832 0.004 0.840 0.000 0.910 0.000 0.670 0.000 Download
MACCS fingerprints 0.890 0.000 0.802 0.000 0.846 0.005 0.850 0.000 0.930 0.000 0.691 0.003 Download
Daylight fingerprints 0.820 0.000 0.938 0.000 0.879 0.003 0.870 0.000 0.919 0.003 0.758 0.004 Download
ECFP2 fingerprints 0.910 0.000 0.930 0.000 0.920 0.000 0.920 0.000 0.970 0.000 0.840 0.000 Download
ECFP4 fingerprints 0.920 0.000 0.960 0.003 0.940 0.000 0.940 0.000 0.980 0.000 0.888 0.004 Download
ECFP6 fingerprints 0.880 0.000 0.962 0.000 0.921 0.003 0.920 0.000 0.980 0.000 0.850 0.000 Download
  Download datasets
Positive dataset Negative dataset

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 E-mail: biomed@csu.edu.cn