Target name

P32300: Delta-type opioid receptor


  Protein function

G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. Plays a role in developing analgesic tolerance to morphine.

  Database links

Uniprot primary ID P32300
PDB ID 4EJ4
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID 317
PharmGKB ID
KEGG ID mmu:18386
DIP ID DIP-46417N
STRING ID 10090.ENSMUSP00000050077
IntAct ID P32300
DMDM
BRENDA
Reactome R-MMU-375276 R-MMU-418594
SignaLink
BioCyc
Entrez Gene (Gene ID) 18386
BindingDB P32300

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.875 0.005 0.865 0.000 0.870 0.000 0.870 0.000 0.940 0.000 0.736 0.005 Download
Estate fingerprints 0.870 0.000 0.828 0.000 0.849 0.003 0.850 0.000 0.920 0.000 0.693 0.005 Download
MACCS fingerprints 0.860 0.000 0.818 0.000 0.839 0.003 0.840 0.000 0.920 0.000 0.675 0.005 Download
Daylight fingerprints 0.749 0.003 0.921 0.000 0.835 0.005 0.820 0.000 0.895 0.005 0.681 0.003 Download
ECFP2 fingerprints 0.950 0.000 0.950 0.000 0.950 0.000 0.950 0.000 0.970 0.000 0.898 0.004 Download
ECFP4 fingerprints 0.930 0.000 0.970 0.000 0.950 0.000 0.950 0.000 0.980 0.000 0.900 0.000 Download
ECFP6 fingerprints 0.919 0.003 0.969 0.000 0.944 0.005 0.940 0.000 0.970 0.000 0.890 0.000 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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