This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. This receptor is implicated in the regulation of mammalian circadian rhythms.
| Uniprot primary ID | P32305 |
| PDB ID | |
| DrugBank ID | |
| BioGrid ID | |
| GuidetoPHARMACOLOGY ID | 12 |
| PharmGKB ID | |
| KEGG ID | rno:103694905 rno:65032 |
| DIP ID | |
| STRING ID | 10116.ENSRNOP00000025450 |
| IntAct ID | |
| DMDM | |
| BRENDA | |
| Reactome | R-RNO-390666 R-RNO-418555 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 103694905;65032 |
| BindingDB | P32305 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.919 | 0.003 | 0.841 | 0.005 | 0.880 | 0.000 | 0.888 | 0.004 | 0.947 | 0.005 | 0.765 | 0.005 | Download |
| Estate fingerprints | 0.872 | 0.004 | 0.800 | 0.007 | 0.836 | 0.005 | 0.842 | 0.004 | 0.900 | 0.000 | 0.672 | 0.008 | Download |
| MACCS fingerprints | 0.909 | 0.007 | 0.813 | 0.006 | 0.861 | 0.003 | 0.869 | 0.006 | 0.930 | 0.000 | 0.727 | 0.007 | Download |
| Daylight fingerprints | 0.746 | 0.005 | 0.814 | 0.004 | 0.780 | 0.000 | 0.775 | 0.005 | 0.840 | 0.000 | 0.566 | 0.005 | Download |
| ECFP2 fingerprints | 0.966 | 0.005 | 0.926 | 0.005 | 0.946 | 0.005 | 0.947 | 0.005 | 0.990 | 0.000 | 0.890 | 0.007 | Download |
| ECFP4 fingerprints | 0.958 | 0.004 | 0.968 | 0.003 | 0.963 | 0.005 | 0.962 | 0.004 | 0.990 | 0.000 | 0.925 | 0.005 | Download |
| ECFP6 fingerprints | 0.927 | 0.005 | 0.991 | 0.005 | 0.959 | 0.003 | 0.957 | 0.005 | 0.990 | 0.000 | 0.914 | 0.005 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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