Target name

P32305: 5-hydroxytryptamine receptor 7


  Protein function

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. This receptor is implicated in the regulation of mammalian circadian rhythms.

  Database links

Uniprot primary ID P32305
PDB ID
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID 12
PharmGKB ID
KEGG ID rno:103694905 rno:65032
DIP ID
STRING ID 10116.ENSRNOP00000025450
IntAct ID
DMDM
BRENDA
Reactome R-RNO-390666 R-RNO-418555
SignaLink
BioCyc
Entrez Gene (Gene ID) 103694905;65032
BindingDB P32305

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.919 0.003 0.841 0.005 0.880 0.000 0.888 0.004 0.947 0.005 0.765 0.005 Download
Estate fingerprints 0.872 0.004 0.800 0.007 0.836 0.005 0.842 0.004 0.900 0.000 0.672 0.008 Download
MACCS fingerprints 0.909 0.007 0.813 0.006 0.861 0.003 0.869 0.006 0.930 0.000 0.727 0.007 Download
Daylight fingerprints 0.746 0.005 0.814 0.004 0.780 0.000 0.775 0.005 0.840 0.000 0.566 0.005 Download
ECFP2 fingerprints 0.966 0.005 0.926 0.005 0.946 0.005 0.947 0.005 0.990 0.000 0.890 0.007 Download
ECFP4 fingerprints 0.958 0.004 0.968 0.003 0.963 0.005 0.962 0.004 0.990 0.000 0.925 0.005 Download
ECFP6 fingerprints 0.927 0.005 0.991 0.005 0.959 0.003 0.957 0.005 0.990 0.000 0.914 0.005 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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