Target name

P33032: Melanocortin receptor 5


  Protein function

Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. This receptor is a possible mediator of the immunomodulation properties of melanocortins.

  Database links

Uniprot primary ID P33032
PDB ID
DrugBank ID
BioGrid ID 110331
GuidetoPHARMACOLOGY ID 286
PharmGKB ID PA30677
KEGG ID hsa:4161
DIP ID DIP-48792N
STRING ID 9606.ENSP00000318077
IntAct ID P33032
DMDM 729996
BRENDA
Reactome R-HSA-418555 R-HSA-375276
SignaLink
BioCyc
Entrez Gene (Gene ID) 4161
BindingDB P33032

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.947 0.005 0.913 0.000 0.930 0.000 0.931 0.003 0.970 0.000 0.858 0.006 Download
Estate fingerprints 0.917 0.005 0.861 0.005 0.889 0.003 0.891 0.003 0.950 0.000 0.780 0.005 Download
MACCS fingerprints 0.922 0.004 0.848 0.006 0.885 0.005 0.890 0.000 0.960 0.000 0.774 0.005 Download
Daylight fingerprints 0.846 0.005 0.936 0.000 0.891 0.003 0.889 0.003 0.940 0.000 0.790 0.005 Download
ECFP2 fingerprints 0.947 0.005 0.947 0.003 0.947 0.005 0.947 0.005 0.980 0.000 0.896 0.007 Download
ECFP4 fingerprints 0.926 0.005 0.964 0.003 0.945 0.005 0.943 0.005 0.990 0.000 0.890 0.000 Download
ECFP6 fingerprints 0.886 0.005 0.974 0.000 0.930 0.000 0.927 0.005 0.988 0.004 0.864 0.005 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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