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E-mail: biomed@csu.edu.cn
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Bifunctional enzyme. The C-terminal domain has epoxide hydrolase activity and acts on epoxides (alkene oxides, oxiranes) and arene oxides. Plays a role in xenobiotic metabolism by degrading potentially toxic epoxides. Also determines steady-state levels of physiological mediators. The N-terminal domain has lipid phosphatase activity, with the highest activity towards threo-9,10-phosphonooxy-hydroxy-octadecanoic acid, followed by erythro-9,10-phosphonooxy-hydroxy-octadecanoic acid, 12-phosphonooxy-octadec-9Z-enoic acid, 12-phosphonooxy-octadec-9E-enoic acid, and p-nitrophenyl phospate.
| Uniprot primary ID | P34913 |
| PDB ID | 5ALF 5ALG 5ALD 5ALE 5ALN 5ALO 5ALL 5ALM 5ALJ 5ALK 5ALH 5ALI 5ALV 5ALW 5ALT 5ALU 5ALR 5ALS 5ALP 5ALQ 5ALZ 5ALX 5ALY 4J03 3WKE 3WKD 3WKC 3WKB 3WKA 4C4X 5AKZ 5AKY 5AKX 5AM1 5AM0 5AM3 5AM2 3I1Y 3ANT 3ANS 4OD0 3OTQ 3WK7 3WK6 3WK5 3WK4 4JNC 5AKG 3WK9 3WK8 5AKE |
| DrugBank ID | |
| BioGrid ID | 108367 |
| GuidetoPHARMACOLOGY ID | |
| PharmGKB ID | PA27830 |
| KEGG ID | hsa:2053 |
| DIP ID | |
| STRING ID | 9606.ENSP00000430269 |
| IntAct ID | P34913 |
| DMDM | 67476665 |
| BRENDA | 3.3.2.10 |
| Reactome | R-HSA-2142670 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 2053 |
| BindingDB | P34913 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.833 | 0.005 | 0.867 | 0.000 | 0.850 | 0.000 | 0.850 | 0.000 | 0.937 | 0.005 | 0.706 | 0.005 | Download |
| Estate fingerprints | 0.877 | 0.005 | 0.823 | 0.004 | 0.850 | 0.000 | 0.853 | 0.005 | 0.910 | 0.000 | 0.701 | 0.007 | Download |
| MACCS fingerprints | 0.870 | 0.000 | 0.896 | 0.000 | 0.883 | 0.005 | 0.880 | 0.000 | 0.940 | 0.000 | 0.770 | 0.000 | Download |
| Daylight fingerprints | 0.750 | 0.000 | 0.850 | 0.005 | 0.800 | 0.000 | 0.790 | 0.000 | 0.850 | 0.000 | 0.600 | 0.000 | Download |
| ECFP2 fingerprints | 0.919 | 0.003 | 0.945 | 0.003 | 0.932 | 0.004 | 0.931 | 0.003 | 0.980 | 0.000 | 0.868 | 0.004 | Download |
| ECFP4 fingerprints | 0.940 | 0.000 | 0.968 | 0.000 | 0.954 | 0.005 | 0.953 | 0.005 | 0.990 | 0.000 | 0.910 | 0.000 | Download |
| ECFP6 fingerprints | 0.918 | 0.004 | 0.982 | 0.005 | 0.950 | 0.000 | 0.950 | 0.000 | 0.990 | 0.000 | 0.903 | 0.005 | Download |
| Positive dataset | Negative dataset |
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E-mail: biomed@csu.edu.cn
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