Target name

P34913: Bifunctional epoxide hydrolase 2


  Protein function

Bifunctional enzyme. The C-terminal domain has epoxide hydrolase activity and acts on epoxides (alkene oxides, oxiranes) and arene oxides. Plays a role in xenobiotic metabolism by degrading potentially toxic epoxides. Also determines steady-state levels of physiological mediators. The N-terminal domain has lipid phosphatase activity, with the highest activity towards threo-9,10-phosphonooxy-hydroxy-octadecanoic acid, followed by erythro-9,10-phosphonooxy-hydroxy-octadecanoic acid, 12-phosphonooxy-octadec-9Z-enoic acid, 12-phosphonooxy-octadec-9E-enoic acid, and p-nitrophenyl phospate.

  Database links

Uniprot primary ID P34913
PDB ID 5ALF 5ALG 5ALD 5ALE 5ALN 5ALO 5ALL 5ALM 5ALJ 5ALK 5ALH 5ALI 5ALV 5ALW 5ALT 5ALU 5ALR 5ALS 5ALP 5ALQ 5ALZ 5ALX 5ALY 4J03 3WKE 3WKD 3WKC 3WKB 3WKA 4C4X 5AKZ 5AKY 5AKX 5AM1 5AM0 5AM3 5AM2 3I1Y 3ANT 3ANS 4OD0 3OTQ 3WK7 3WK6 3WK5 3WK4 4JNC 5AKG 3WK9 3WK8 5AKE
DrugBank ID
BioGrid ID 108367
GuidetoPHARMACOLOGY ID
PharmGKB ID PA27830
KEGG ID hsa:2053
DIP ID
STRING ID 9606.ENSP00000430269
IntAct ID P34913
DMDM 67476665
BRENDA 3.3.2.10
Reactome R-HSA-2142670
SignaLink
BioCyc
Entrez Gene (Gene ID) 2053
BindingDB P34913

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.833 0.005 0.867 0.000 0.850 0.000 0.850 0.000 0.937 0.005 0.706 0.005 Download
Estate fingerprints 0.877 0.005 0.823 0.004 0.850 0.000 0.853 0.005 0.910 0.000 0.701 0.007 Download
MACCS fingerprints 0.870 0.000 0.896 0.000 0.883 0.005 0.880 0.000 0.940 0.000 0.770 0.000 Download
Daylight fingerprints 0.750 0.000 0.850 0.005 0.800 0.000 0.790 0.000 0.850 0.000 0.600 0.000 Download
ECFP2 fingerprints 0.919 0.003 0.945 0.003 0.932 0.004 0.931 0.003 0.980 0.000 0.868 0.004 Download
ECFP4 fingerprints 0.940 0.000 0.968 0.000 0.954 0.005 0.953 0.005 0.990 0.000 0.910 0.000 Download
ECFP6 fingerprints 0.918 0.004 0.982 0.005 0.950 0.000 0.950 0.000 0.990 0.000 0.903 0.005 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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