G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.
| Uniprot primary ID | P34975 |
| PDB ID | |
| DrugBank ID | |
| BioGrid ID | |
| GuidetoPHARMACOLOGY ID | 318 |
| PharmGKB ID | |
| KEGG ID | rno:29335 |
| DIP ID | |
| STRING ID | 10116.ENSRNOP00000010255 |
| IntAct ID | P34975 |
| DMDM | |
| BRENDA | |
| Reactome | R-RNO-418594 R-RNO-375276 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 29335 |
| BindingDB | P34975 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.820 | 0.000 | 0.856 | 0.010 | 0.838 | 0.006 | 0.837 | 0.005 | 0.910 | 0.000 | 0.679 | 0.009 | Download |
| Estate fingerprints | 0.909 | 0.006 | 0.757 | 0.011 | 0.833 | 0.008 | 0.846 | 0.005 | 0.910 | 0.005 | 0.674 | 0.013 | Download |
| MACCS fingerprints | 0.848 | 0.008 | 0.782 | 0.011 | 0.815 | 0.008 | 0.821 | 0.006 | 0.890 | 0.000 | 0.633 | 0.016 | Download |
| Daylight fingerprints | 0.667 | 0.013 | 0.881 | 0.010 | 0.774 | 0.010 | 0.745 | 0.011 | 0.827 | 0.008 | 0.561 | 0.021 | Download |
| ECFP2 fingerprints | 0.882 | 0.004 | 0.890 | 0.009 | 0.886 | 0.005 | 0.886 | 0.005 | 0.950 | 0.000 | 0.772 | 0.006 | Download |
| ECFP4 fingerprints | 0.863 | 0.007 | 0.957 | 0.004 | 0.910 | 0.000 | 0.904 | 0.005 | 0.961 | 0.003 | 0.823 | 0.007 | Download |
| ECFP6 fingerprints | 0.835 | 0.005 | 0.963 | 0.007 | 0.899 | 0.006 | 0.891 | 0.006 | 0.959 | 0.003 | 0.800 | 0.011 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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