Target name

P34975: Kappa-type opioid receptor


  Protein function

G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.

  Database links

Uniprot primary ID P34975
PDB ID
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID 318
PharmGKB ID
KEGG ID rno:29335
DIP ID
STRING ID 10116.ENSRNOP00000010255
IntAct ID P34975
DMDM
BRENDA
Reactome R-RNO-418594 R-RNO-375276
SignaLink
BioCyc
Entrez Gene (Gene ID) 29335
BindingDB P34975

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.820 0.000 0.856 0.010 0.838 0.006 0.837 0.005 0.910 0.000 0.679 0.009 Download
Estate fingerprints 0.909 0.006 0.757 0.011 0.833 0.008 0.846 0.005 0.910 0.005 0.674 0.013 Download
MACCS fingerprints 0.848 0.008 0.782 0.011 0.815 0.008 0.821 0.006 0.890 0.000 0.633 0.016 Download
Daylight fingerprints 0.667 0.013 0.881 0.010 0.774 0.010 0.745 0.011 0.827 0.008 0.561 0.021 Download
ECFP2 fingerprints 0.882 0.004 0.890 0.009 0.886 0.005 0.886 0.005 0.950 0.000 0.772 0.006 Download
ECFP4 fingerprints 0.863 0.007 0.957 0.004 0.910 0.000 0.904 0.005 0.961 0.003 0.823 0.007 Download
ECFP6 fingerprints 0.835 0.005 0.963 0.007 0.899 0.006 0.891 0.006 0.959 0.003 0.800 0.011 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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