Target name

P34995: Prostaglandin E2 receptor EP1 subtype


  Protein function

Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(q) proteins which activate a phosphatidylinositol-calcium second messenger system. May play a role as an important modulator of renal function. Implicated the smooth muscle contractile response to PGE2 in various tissues.

  Database links

Uniprot primary ID P34995
PDB ID
DrugBank ID DB01088 DB00770 DB00297 DB00429 DB00917 DB00905
BioGrid ID 111703
GuidetoPHARMACOLOGY ID 340
PharmGKB ID PA286
KEGG ID hsa:5731
DIP ID
STRING ID 9606.ENSP00000292513
IntAct ID
DMDM 83287886
BRENDA
Reactome R-HSA-391908 R-HSA-416476
SignaLink
BioCyc
Entrez Gene (Gene ID) 5731
BindingDB

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.828 0.006 0.974 0.004 0.901 0.003 0.894 0.005 0.960 0.000 0.815 0.007 Download
Estate fingerprints 0.864 0.005 0.832 0.003 0.848 0.004 0.850 0.000 0.930 0.000 0.697 0.005 Download
MACCS fingerprints 0.795 0.010 0.891 0.000 0.843 0.005 0.836 0.005 0.935 0.005 0.690 0.008 Download
Daylight fingerprints 0.718 0.006 0.986 0.000 0.852 0.004 0.827 0.005 0.900 0.000 0.728 0.006 Download
ECFP2 fingerprints 0.935 0.005 0.945 0.005 0.940 0.000 0.940 0.000 0.990 0.000 0.881 0.007 Download
ECFP4 fingerprints 0.933 0.005 0.987 0.004 0.960 0.000 0.959 0.003 0.990 0.000 0.922 0.006 Download
ECFP6 fingerprints 0.873 0.009 0.993 0.000 0.933 0.005 0.930 0.005 0.980 0.000 0.878 0.008 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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