Target name

P34998: Corticotropin-releasing factor receptor 1


  Protein function

G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to stress. Plays a role in the response to anxiogenic stimuli.

  Database links

Uniprot primary ID P34998
PDB ID 2L27 3EHS 3EHT 3EHU 4K5Y
DrugBank ID
BioGrid ID 107784
GuidetoPHARMACOLOGY ID 212
PharmGKB ID PA26874
KEGG ID hsa:1394 hsa:104909134
DIP ID
STRING ID 9606.ENSP00000381333
IntAct ID P34998
DMDM 461836
BRENDA
Reactome R-HSA-373080 R-HSA-418555
SignaLink
BioCyc
Entrez Gene (Gene ID) 104909134;1394
BindingDB P34998

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.940 0.000 0.900 0.005 0.920 0.000 0.920 0.000 0.960 0.000 0.840 0.000 Download
Estate fingerprints 0.910 0.000 0.868 0.000 0.889 0.003 0.890 0.000 0.940 0.000 0.770 0.000 Download
MACCS fingerprints 0.920 0.000 0.882 0.005 0.901 0.003 0.909 0.003 0.960 0.000 0.810 0.000 Download
Daylight fingerprints 0.800 0.000 0.780 0.003 0.790 0.000 0.790 0.000 0.839 0.003 0.580 0.000 Download
ECFP2 fingerprints 0.950 0.000 0.990 0.000 0.970 0.000 0.968 0.004 0.990 0.000 0.930 0.000 Download
ECFP4 fingerprints 0.957 0.005 0.985 0.000 0.971 0.003 0.971 0.003 0.990 0.000 0.950 0.000 Download
ECFP6 fingerprints 0.940 0.000 1.000 0.000 0.970 0.000 0.970 0.000 0.990 0.000 0.940 0.000 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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