Receptor for somatostatin 28 and to a lesser extent for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Increases cell growth inhibition activity of SSTR2 following heterodimerization.
| Uniprot primary ID | P35346 |
| PDB ID | |
| DrugBank ID | DB00104 DB06663 DB04894 |
| BioGrid ID | 112633 |
| GuidetoPHARMACOLOGY ID | 359 |
| PharmGKB ID | PA36158 |
| KEGG ID | hsa:6755 |
| DIP ID | |
| STRING ID | 9606.ENSP00000293897 |
| IntAct ID | |
| DMDM | 12644225 |
| BRENDA | |
| Reactome | R-HSA-418594 R-HSA-375276 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 6755 |
| BindingDB | P35346 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.706 | 0.005 | 0.954 | 0.000 | 0.830 | 0.000 | 0.806 | 0.005 | 0.950 | 0.000 | 0.678 | 0.004 | Download |
| Estate fingerprints | 0.732 | 0.004 | 0.948 | 0.000 | 0.840 | 0.000 | 0.820 | 0.000 | 0.936 | 0.005 | 0.697 | 0.005 | Download |
| MACCS fingerprints | 0.740 | 0.000 | 0.928 | 0.004 | 0.834 | 0.005 | 0.819 | 0.003 | 0.940 | 0.000 | 0.679 | 0.003 | Download |
| Daylight fingerprints | 0.678 | 0.004 | 0.962 | 0.000 | 0.820 | 0.000 | 0.790 | 0.000 | 0.940 | 0.000 | 0.670 | 0.000 | Download |
| ECFP2 fingerprints | 0.704 | 0.005 | 0.976 | 0.004 | 0.840 | 0.000 | 0.814 | 0.005 | 0.970 | 0.000 | 0.704 | 0.005 | Download |
| ECFP4 fingerprints | 0.738 | 0.006 | 0.982 | 0.005 | 0.860 | 0.000 | 0.841 | 0.003 | 0.990 | 0.000 | 0.742 | 0.004 | Download |
| ECFP6 fingerprints | 0.698 | 0.004 | 0.982 | 0.004 | 0.840 | 0.000 | 0.813 | 0.005 | 0.980 | 0.000 | 0.710 | 0.005 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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