Target name

P35346: Somatostatin receptor type 5


  Protein function

Receptor for somatostatin 28 and to a lesser extent for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Increases cell growth inhibition activity of SSTR2 following heterodimerization.

  Database links

Uniprot primary ID P35346
PDB ID
DrugBank ID DB00104 DB06663 DB04894
BioGrid ID 112633
GuidetoPHARMACOLOGY ID 359
PharmGKB ID PA36158
KEGG ID hsa:6755
DIP ID
STRING ID 9606.ENSP00000293897
IntAct ID
DMDM 12644225
BRENDA
Reactome R-HSA-418594 R-HSA-375276
SignaLink
BioCyc
Entrez Gene (Gene ID) 6755
BindingDB P35346

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.706 0.005 0.954 0.000 0.830 0.000 0.806 0.005 0.950 0.000 0.678 0.004 Download
Estate fingerprints 0.732 0.004 0.948 0.000 0.840 0.000 0.820 0.000 0.936 0.005 0.697 0.005 Download
MACCS fingerprints 0.740 0.000 0.928 0.004 0.834 0.005 0.819 0.003 0.940 0.000 0.679 0.003 Download
Daylight fingerprints 0.678 0.004 0.962 0.000 0.820 0.000 0.790 0.000 0.940 0.000 0.670 0.000 Download
ECFP2 fingerprints 0.704 0.005 0.976 0.004 0.840 0.000 0.814 0.005 0.970 0.000 0.704 0.005 Download
ECFP4 fingerprints 0.738 0.006 0.982 0.005 0.860 0.000 0.841 0.003 0.990 0.000 0.742 0.004 Download
ECFP6 fingerprints 0.698 0.004 0.982 0.004 0.840 0.000 0.813 0.005 0.980 0.000 0.710 0.005 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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