This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes.
| Uniprot primary ID | P35348 |
| PDB ID | |
| DrugBank ID | DB00751 DB00777 DB06148 DB00598 DB01142 DB01049 DB00610 |
| BioGrid ID | |
| GuidetoPHARMACOLOGY ID | 22 |
| PharmGKB ID | PA34 |
| KEGG ID | hsa:148 |
| DIP ID | DIP-33401N |
| STRING ID | 9606.ENSP00000369960 |
| IntAct ID | P35348 |
| DMDM | 1168246 |
| BRENDA | |
| Reactome | R-HSA-390696 R-HSA-416476 R-HSA-416482 |
| SignaLink | P35348 |
| BioCyc | |
| Entrez Gene (Gene ID) | 148 |
| BindingDB | P35348 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.653 | 0.005 | 0.907 | 0.003 | 0.780 | 0.000 | 0.749 | 0.003 | 0.900 | 0.000 | 0.581 | 0.006 | Download |
| Estate fingerprints | 0.749 | 0.003 | 0.701 | 0.005 | 0.725 | 0.005 | 0.730 | 0.000 | 0.830 | 0.000 | 0.452 | 0.004 | Download |
| MACCS fingerprints | 0.780 | 0.000 | 0.740 | 0.005 | 0.760 | 0.000 | 0.764 | 0.005 | 0.847 | 0.005 | 0.519 | 0.003 | Download |
| Daylight fingerprints | 0.617 | 0.005 | 0.943 | 0.004 | 0.780 | 0.000 | 0.738 | 0.004 | 0.900 | 0.000 | 0.595 | 0.005 | Download |
| ECFP2 fingerprints | 0.890 | 0.000 | 0.924 | 0.000 | 0.907 | 0.005 | 0.902 | 0.004 | 0.970 | 0.000 | 0.810 | 0.005 | Download |
| ECFP4 fingerprints | 0.874 | 0.005 | 0.976 | 0.004 | 0.925 | 0.005 | 0.920 | 0.000 | 0.980 | 0.000 | 0.852 | 0.004 | Download |
| ECFP6 fingerprints | 0.837 | 0.005 | 0.983 | 0.000 | 0.910 | 0.000 | 0.902 | 0.004 | 0.971 | 0.003 | 0.830 | 0.000 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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