Target name

P35348: Alpha-1A adrenergic receptor


  Protein function

This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes.

  Database links

Uniprot primary ID P35348
PDB ID
DrugBank ID DB00751 DB00777 DB06148 DB00598 DB01142 DB01049 DB00610
BioGrid ID
GuidetoPHARMACOLOGY ID 22
PharmGKB ID PA34
KEGG ID hsa:148
DIP ID DIP-33401N
STRING ID 9606.ENSP00000369960
IntAct ID P35348
DMDM 1168246
BRENDA
Reactome R-HSA-390696 R-HSA-416476 R-HSA-416482
SignaLink P35348
BioCyc
Entrez Gene (Gene ID) 148
BindingDB P35348

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.653 0.005 0.907 0.003 0.780 0.000 0.749 0.003 0.900 0.000 0.581 0.006 Download
Estate fingerprints 0.749 0.003 0.701 0.005 0.725 0.005 0.730 0.000 0.830 0.000 0.452 0.004 Download
MACCS fingerprints 0.780 0.000 0.740 0.005 0.760 0.000 0.764 0.005 0.847 0.005 0.519 0.003 Download
Daylight fingerprints 0.617 0.005 0.943 0.004 0.780 0.000 0.738 0.004 0.900 0.000 0.595 0.005 Download
ECFP2 fingerprints 0.890 0.000 0.924 0.000 0.907 0.005 0.902 0.004 0.970 0.000 0.810 0.005 Download
ECFP4 fingerprints 0.874 0.005 0.976 0.004 0.925 0.005 0.920 0.000 0.980 0.000 0.852 0.004 Download
ECFP6 fingerprints 0.837 0.005 0.983 0.000 0.910 0.000 0.902 0.004 0.971 0.003 0.830 0.000 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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