The recommended browsers: Safari, Firefox, Chrome, IE(Ver.>8).
E-mail: biomed@csu.edu.cn
 |
 |
 |
 |
 |
 |
Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays important roles in modulating motility, proliferation and resistance to apoptosis.
| Uniprot primary ID | P35354 |
| PDB ID | 1V0X |
| DrugBank ID | DB01419 DB00480 DB00159 DB00773 DB00991 DB01628 DB06725 |
| BioGrid ID | 111715 |
| GuidetoPHARMACOLOGY ID | 1376 |
| PharmGKB ID | PA293 |
| KEGG ID | hsa:5743 |
| DIP ID | DIP-28131N |
| STRING ID | 9606.ENSP00000356438 |
| IntAct ID | P35354 |
| DMDM | 3915797 |
| BRENDA | 1.14.99.1 |
| Reactome | R-HSA-197264 R-HSA-2142770 R-HSA-2162123 |
| SignaLink | |
| BioCyc | MetaCyc:HS01115-MONOMER |
| Entrez Gene (Gene ID) | 5743 |
| BindingDB | P35354 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.819 | 0.003 | 0.901 | 0.005 | 0.860 | 0.000 | 0.853 | 0.005 | 0.940 | 0.000 | 0.725 | 0.005 | Download |
| Estate fingerprints | 0.774 | 0.005 | 0.886 | 0.000 | 0.830 | 0.000 | 0.820 | 0.000 | 0.920 | 0.000 | 0.660 | 0.000 | Download |
| MACCS fingerprints | 0.780 | 0.000 | 0.880 | 0.003 | 0.830 | 0.000 | 0.820 | 0.000 | 0.920 | 0.000 | 0.669 | 0.003 | Download |
| Daylight fingerprints | 0.770 | 0.000 | 0.810 | 0.000 | 0.790 | 0.000 | 0.785 | 0.005 | 0.855 | 0.005 | 0.580 | 0.000 | Download |
| ECFP2 fingerprints | 0.867 | 0.005 | 0.925 | 0.003 | 0.896 | 0.005 | 0.890 | 0.000 | 0.970 | 0.000 | 0.790 | 0.000 | Download |
| ECFP4 fingerprints | 0.860 | 0.000 | 0.960 | 0.000 | 0.910 | 0.000 | 0.909 | 0.003 | 0.980 | 0.000 | 0.821 | 0.003 | Download |
| ECFP6 fingerprints | 0.850 | 0.000 | 0.970 | 0.000 | 0.910 | 0.000 | 0.900 | 0.000 | 0.970 | 0.000 | 0.820 | 0.000 | Download |
| Positive dataset | Negative dataset |
The recommended browsers: Safari, Firefox, Chrome, IE(Ver.>8).
E-mail: biomed@csu.edu.cn
| |
|
|
| |
|
|