Target name

P35354: Prostaglandin G/H synthase 2


  Protein function

Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays important roles in modulating motility, proliferation and resistance to apoptosis.

  Database links

Uniprot primary ID P35354
PDB ID 1V0X
DrugBank ID DB01419 DB00480 DB00159 DB00773 DB00991 DB01628 DB06725
BioGrid ID 111715
GuidetoPHARMACOLOGY ID 1376
PharmGKB ID PA293
KEGG ID hsa:5743
DIP ID DIP-28131N
STRING ID 9606.ENSP00000356438
IntAct ID P35354
DMDM 3915797
BRENDA 1.14.99.1
Reactome R-HSA-197264 R-HSA-2142770 R-HSA-2162123
SignaLink
BioCyc MetaCyc:HS01115-MONOMER
Entrez Gene (Gene ID) 5743
BindingDB P35354

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.819 0.003 0.901 0.005 0.860 0.000 0.853 0.005 0.940 0.000 0.725 0.005 Download
Estate fingerprints 0.774 0.005 0.886 0.000 0.830 0.000 0.820 0.000 0.920 0.000 0.660 0.000 Download
MACCS fingerprints 0.780 0.000 0.880 0.003 0.830 0.000 0.820 0.000 0.920 0.000 0.669 0.003 Download
Daylight fingerprints 0.770 0.000 0.810 0.000 0.790 0.000 0.785 0.005 0.855 0.005 0.580 0.000 Download
ECFP2 fingerprints 0.867 0.005 0.925 0.003 0.896 0.005 0.890 0.000 0.970 0.000 0.790 0.000 Download
ECFP4 fingerprints 0.860 0.000 0.960 0.000 0.910 0.000 0.909 0.003 0.980 0.000 0.821 0.003 Download
ECFP6 fingerprints 0.850 0.000 0.970 0.000 0.910 0.000 0.900 0.000 0.970 0.000 0.820 0.000 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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