Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function.
| Uniprot primary ID | P35408 |
| PDB ID | |
| DrugBank ID | DB00917 DB00929 |
| BioGrid ID | 111706 |
| GuidetoPHARMACOLOGY ID | 343 |
| PharmGKB ID | PA289 |
| KEGG ID | hsa:5734 |
| DIP ID | DIP-61099N |
| STRING ID | 9606.ENSP00000302846 |
| IntAct ID | |
| DMDM | 548476 |
| BRENDA | |
| Reactome | R-HSA-391908 R-HSA-418555 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 5734 |
| BindingDB | P35408 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.930 | 0.005 | 0.910 | 0.004 | 0.920 | 0.000 | 0.921 | 0.003 | 0.968 | 0.004 | 0.841 | 0.006 | Download |
| Estate fingerprints | 0.890 | 0.011 | 0.744 | 0.006 | 0.817 | 0.007 | 0.828 | 0.006 | 0.891 | 0.003 | 0.641 | 0.014 | Download |
| MACCS fingerprints | 0.913 | 0.005 | 0.831 | 0.003 | 0.872 | 0.004 | 0.879 | 0.003 | 0.936 | 0.005 | 0.748 | 0.006 | Download |
| Daylight fingerprints | 0.891 | 0.009 | 0.843 | 0.007 | 0.867 | 0.007 | 0.870 | 0.007 | 0.908 | 0.004 | 0.734 | 0.011 | Download |
| ECFP2 fingerprints | 0.980 | 0.000 | 0.944 | 0.000 | 0.962 | 0.004 | 0.962 | 0.004 | 0.991 | 0.003 | 0.923 | 0.005 | Download |
| ECFP4 fingerprints | 0.969 | 0.003 | 0.971 | 0.004 | 0.970 | 0.000 | 0.970 | 0.000 | 0.999 | 0.003 | 0.945 | 0.007 | Download |
| ECFP6 fingerprints | 0.945 | 0.005 | 0.995 | 0.000 | 0.970 | 0.000 | 0.970 | 0.000 | 0.993 | 0.005 | 0.944 | 0.005 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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