TargetNet
  Target name

P35408: Prostaglandin E2 receptor EP4 subtype

  Protein function

Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function.

  Database links
Uniprot primary ID P35408
PDB ID
DrugBank ID DB00917 DB00929
BioGrid ID 111706
GuidetoPHARMACOLOGY ID 343
PharmGKB ID PA289
KEGG ID hsa:5734
DIP ID DIP-61099N
STRING ID 9606.ENSP00000302846
IntAct ID
DMDM 548476
BRENDA
Reactome R-HSA-391908 R-HSA-418555
SignaLink
BioCyc
Entrez Gene (Gene ID) 5734
BindingDB P35408
  Model Performance Metrics
Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.930 0.005 0.910 0.004 0.920 0.000 0.921 0.003 0.968 0.004 0.841 0.006 Download
Estate fingerprints 0.890 0.011 0.744 0.006 0.817 0.007 0.828 0.006 0.891 0.003 0.641 0.014 Download
MACCS fingerprints 0.913 0.005 0.831 0.003 0.872 0.004 0.879 0.003 0.936 0.005 0.748 0.006 Download
Daylight fingerprints 0.891 0.009 0.843 0.007 0.867 0.007 0.870 0.007 0.908 0.004 0.734 0.011 Download
ECFP2 fingerprints 0.980 0.000 0.944 0.000 0.962 0.004 0.962 0.004 0.991 0.003 0.923 0.005 Download
ECFP4 fingerprints 0.969 0.003 0.971 0.004 0.970 0.000 0.970 0.000 0.999 0.003 0.945 0.007 Download
ECFP6 fingerprints 0.945 0.005 0.995 0.000 0.970 0.000 0.970 0.000 0.993 0.005 0.944 0.005 Download
  Download datasets
Positive dataset Negative dataset

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 E-mail: biomed@csu.edu.cn